Nano CBD VS Regular CBD

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What is the difference between Nano CBD VS regular CBD? 20 years ago hemp-based CBD manufacturers were unheard of outside the cannabis community. Now you can’t go a day without seeing an ad for a new way to get your CBD.

So many are still mystified by CBD. What is it, where does it come from, how is it different from marijuana?

People who never saw themselves as supporters of the cannabis industry are suddenly lathering up their CBD-infused hand cream.

And now, with the addition of nano CBD, it seems like the confusion is just starting.

Why It’s Not a Competition

Nano CBD can be a great addition to any morning routine, but it doesn’t mean other forms of the cannabinoid should be tossed like last week’s leftovers.

Nanotechnology is like taking microscopic molecules to the mechanic. Without any work done, CBD oil can’t dissolve into water.

That puts a cap on what it can be added to because fat is needed to make everything mix together.

What if there were a way to cheat chemistry? That’s exactly what nanotechnology is all about.

Manipulating particles at the smallest levels to get them to act in a way they don’t in nature.

CB1 VS CB2 Receptors

Before we start it’s important to know the basic mechanisms behind how CBD works.

THC, the psychoactive compound in marijuana, binds directly to both CB1 and CB2 receptors.

Rather than follow in the footsteps of its intoxicating cousin, CBD instead slows down CB2 receptors.

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This is why CBD has no psychoactive effects. Rather than play directly into the endocannabinoid system, it instead changes how fast everything is happening.

Because of CB2 receptors’ proximity to the immune system, they are in charge of inflammatory responses.

When a biker falls off her bike, CB2 receptors are quick to cause inflammation to begin the healing process.

Nano CBD VS Full-Spectrum

Many consumers still don’t know there are many more cannabinoids than just THC and CBD.

This is the theory behind full-spectrum CBD oil. Because these molecules work together in nature, they must perform better in the body as a team.

This is known as the “entourage effect”. When you take a swig of full-spectrum oil you’re getting all these other cannabinoids. There are 113 known cannabinoids.

Every strain is going to have different levels of each. Just like there are plants high in CBD, some are high in cannabigerol (CBG).

And cannabinoids are just one component of the hemp plant. All plants contain terpenes.

They’re what make fresh mint smell so good and tropical fruits smell funky. But they do much more than smell good.


Terpenes are an integral part of US-based hemp manufacturer’s full-spectrum CBD oil. It’s important to know what you’re cutting out when you opt for products, like nano CBD oil.

They’re quick to be absorbed into the bloodstream. And just like CBD, they can bind to receptors in the brain.

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Beta-caryophyllene is a terpene found in black pepper that can bind to CB2 receptors. The bulk of CB2 receptors live in the immune system.

CBD acts as a plug for CB2 receptors. Neurotransmitters can’t pass through as fast as they’re programmed to.

Because terpene beta-caryophyllene also binds to the CB2 receptors it raises questions about how it affects CBD supplements.

It’s why the burst of lavender from your massage therapist’s diffuser instantly relaxes you. There are over 200 terpenes found in the hemp plant, but most of them are in tiny amounts.

What are these compounds there for? Since plants can’t move to escape their predators they’ve evolved to avoid being eaten.

Strong, oily terpenes ward off pests and herbivores. But they aren’t necessarily bad for us.

Pure CBD

Pure CBD could easily be mistaken for some chalky whey protein powder. Without any of the other plant matter, cannabinoids, or water CBD looks, unlike anything you’d expect a stalk of hemp to yield.

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Full-spectrum CBD oil is great for customers looking for the benefits of the entire hemp plant.

But if the presence of all these other compounds affects the body’s ability to process CBD, then it’s to be expected some customers will want pure CBD.

So how do we turn hemp fiber into pure white nano CBD powder? It all starts at the farm.

Harvesting Hemp

Some hemp manufacturers test their crops’ CBD content weekly to know when to harvest. Once the plants are cut, they need to start drying as soon as possible to prevent mold.

Harvesting before the hemp has reached its full potential can cost a farmer big time. For every 1000 lbs of raw hemp, a 1% difference in CBD content can mean losing 10 pounds or more of CBD oil.

Curing the plants can take a lot of energy. Temperatures have to be a steady 60-70 degrees Fahrenheit with a humidity of around 60%.

The plants are at their most vulnerable. Mold, fungus, and pests could ruin what would have been a great harvest.

Turning Hemp Into Nano CBD

There are three methods to “winterize” hemp. Ethanol, butane, and carbon dioxide can all be used to extract the initial oils from the plant.

Winterization is the process of extracting the oils from the raw plant matter. Once the oil is pulled, it’s still raw.

To isolate the CBD further processing is needed. Distillation brings us a step closer to our final product.

When the oil is heated, all the different compounds start to separate because of their different boiling points.

So any compound from the hemp plant, not just CBD, can be isolated this way. Once we get CBD all alone it’s ready for a nanotechnology makeover.

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History of Nanotech

How did nanotechnology start? It sounds futuristic but scientists have been talking about the potential of nanotech since 1959.

Richard Feynman, a renowned physicist, brought up the subject at a conference that year. But it was still far from a reality.

It wouldn’t be until the next year that two engineers used nanotechnology for the first time in a semiconductor.

They stretched a type of metal so thin it had to be measured in nanometers. This is where some of the confusion around nanotechnology comes from.

Because it’s a broad term including any engineering at the nano level of measurements, it’s not limited to one industry.

The term gained popularity in the 2000s as brands and consumers misunderstood what nanotechnology really is–and more important–what it isn’t.

Why CBD Manufacturers Are Using Nanotechnology

The first pass effect is the body’s bouncer. When you ingest CBD it’s going to hit your liver and gut wall before going into effect.

This step is where a lot of the potency of CBD products is lost. Best case scenario, the body absorbs around 20% of the CBD taken.

But bioavailability levels can be as low as 4%. You could be getting as little as 4 mg out of that 100 mg soft gel you just took.

Vaporizing is much more effective but the long-term health effects are unknown. With cautionary tales of strange illnesses developing from vaping, it’s not a risk worth taking.

In comes nanotechnology. The main reason CBD has a hard time assimilating into the body is its reaction to water.

CBD doesn’t mix in water. Since our bodies are more water than anything else, we end up getting only a sliver of the CBD we take.

Some private label CBD manufacturers label their nano CBD as “water-soluble CBD”. It might seem that way when you see products, like CBD water, which seem to defy physics.

But it’s important to remember the science behind nano CBD. When molecules are broken, they no longer behave the same way.

Just like breaking down water produces hydrogen and oxygen. Without the whole party there, it doesn’t work.

Nano CBD is still CBD. By wrapping each molecule in a matrix of water-soluble chemicals, the surface tension changes.


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The theory behind this process is an attempt to circumvent the first-pass effect. This is a huge upgrade from waiting for the body to break down CBD into a digestible form.

By cutting out this step where most of the potency is lost, the CBD should be able to reach the bloodstream faster.

There is promising research showing nanotechnology as a successful means of delivering pharmaceuticals, it’s yet to be proven for CBD.

This is why providing customers with options and the knowledge to make informed decisions is key to success in this industry.


The chemicals used to coat the surface of nano CBD molecules often contain what are known as “penetration-enhancers”.

They’ve been used for years to deliver intravenous drugs to patients. They work by dissolving the membrane the drug would have to cross under normal circumstances.

Because CBD has low bioavailability when taken orally, there are studies that show it is a good candidate to enhance with nanotechnology.

Encasing CBD with surfactants and penetration-enhancers has another added benefit. Increased surface area means it should be easier for the body to absorb than regular CBD oil.

It’s inevitable your customers will have questions about this new form of CBD. They’ll be asking what these added surfactants are made of.

What Are They Made Of?

Are they safe to take in the amounts present in nano CBD products? A common surfactant is propylene glycol.

The cosmetic industry uses propylene glycol like it’s going out of business. There is a lot of irony in the fact that an industry making products for your skin use an ingredient named “allergen of the year”.

Of course, allergies vary from person to person, but it’s important to note that nano CBD by nature must include other ingredients as surfactants.

Not all surfactants are equal. Cyclodextrin is another common surfactant added to many food and cosmetic products.

It is recognized as safe by the FDA and doesn’t have the allergy reputation propylene glycol has.

Interestingly one of the most promising uses of surfactants is for eye medication.

Cyclodextrin is able to wiggle through the gaps between membranes to deliver a more potent dose.

Could CBD eye drops be a product of the future? Will eye drops be the perfect compromise between vaping and oral supplements?

This is complete speculation of course, but with nano CBD in its infancy, it’s fun to explore potential uses for it.

Starting a Nano CBD Regime

Standard CBD oil is best for customers looking to get their toes wet. Starting with regular CBD allows users to see if they even need a more purified form.

Before making the jump to offering nano CBD make sure your customers know the best ways to use regular CBD.

A meal full of healthy fats prior to taking CBD can help with delivery. Gargling some CBD oil can also help it reach all the membranes in your mouth where absorption can take place.

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Natural emulsifiers may work also. You don’t need expensive nanotechnology equipment either.

A spoon full of honey is a bit like a natural surfactant for CBD.

Half as Potent?

While nano CBD particles may enter the bloodstream faster, some worry this means it exits the body just as fast.

So it may take half as long to see benefits but also lasts half as long as regular CBD oil. The question of whether this is any better than taking a larger dose of regular old CBD oil.

It’s almost a choice between short and intense or long but steady. It comes down to individual preference and what works best for each customer.

The other issue with this is that more than half of CBD products incorrectly list their contents.

From dangerous additives to excessive CBD, researchers have seen it all. So many doctors and scientists were concerned over the inclusion of nanotechnology into so many different industries that nanotoxicology is now a field of study.

There are many unanswered questions when it comes to putting nano-sized chemicals into our bodies.

Nanotoxicology looks at the physiological effects of opening the door to nano-particles. Remember that the first pass effect is one of the body’s first lines of defense.

Could bypass it with nano CBD be potentially dangerous? CBD goes from passing through the entire intestinal tract to interacting directly with membranes.

Be Wary of Fraud

Because little is known about it nano CBD is easy pickings for scammers. Three of the CBD water brands tested by industry experts at Leafly contained 0% CBD.

The company’s defense was that their patented process produces nano CBD that is so small it can’t be tested for.

This makes no sense. Like we covered, nanotech doesn’t change the chemical structure of CBD.

It’s simply a delivery system. By adding a solvent to remove the surfactants there is still plain CBD underneath.

So it doesn’t add up that this one brand’s CBD is untestable. Add to this the fact different labs can report back different results and who is to say one is more right than the other?

These limitations are brought on by a lack of regulations. Even though the 0.3% THC limit is strict, it’s one of the first real standards expected of the CBD industry.

These testing facilities have their own set of problems. ABC Testing, a popular hemp testing facility, received an official warning letter from the FDA and failed to do anything to improve.

They couldn’t prove their testing methods were even valid. Two batches of the exact same hemp could come through but show completely different cannabinoid profiles.

Their computer system was unsecured, allowing any unauthorized employee or hacker to potentially alter their records.

It’s not Just CBD Dropping The Ball

The same lab was tasked with testing for the presence of a certain bacteria in a stool-softening drug.

The lab said there were no bacteria, but a follow-up test by both the FDA and CDC proved otherwise.

This is really bad. These labs are being used for all kinds of products and pharmaceuticals, not just CBD.

Problems with CBD lab testing is starting to shed light on bigger problems throughout other consumer good industries.

How to start selling Nano CBD

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Whether you’re looking to branch out into nano CBD, full-spectrum oil, or nano CBD cream, Spring Creek Labs has everything needed to get started selling private label CBD products.

Unlike some Nano CBD manufacturers who are forced to source their raw materials from growers all over the world, here at Spring Creek Labs we own all our farms.

It’s why we’re able to offer great prices, low minimum orders, all while offering higher-quality CBD than the competition.

Single-origin hemp plants with almost no THC grow until maturity on Spring Creek Labs’ farms.

All our hemp tests below the federal 0.3% limit, but we also offer THC-free products as well.

No forwarding to third-party couriers or processors. No unlisted dangerous additives.

With a buffet of different private label products, CBD products to choose from you can test new products and keep the ones your customers can’t live without.

It all starts with an email. Send us one now and get a free quote today!

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