Current CBD Studies and What They Mean

Welcome to our on the article on Current CBD Studies. This article is brought to you by Spring Creek Labs, a U.S. Based CBD Manufacturer and Private Label CBD Product Fulfillment Company.

Cannabidiol (CBD) is one of 113 compounds that has been isolated from cannabis. It’s not a psychoactive compound; it doesn’t get you high.

Still, CBD is proving to be one of the most fascinating substances on earth. Millions of people swear by the healing powers of CBD, even though just 10 years ago it was impossible to find.

It wasn’t until the US Congress passed the 2018 Farm Bill and made industrial hemp legal across the US was there a willingness to study hemp. Before that, labs, hospitals, and pharmaceutical companies didn’t want to run afoul of the US government’s drug laws. Today (August 2021), there are hundreds of clinical studies being done on the effects of CBD, both with and without THC.

Disclaimer: This is not medical advice. This article is not a medical evaluation of these studies; it’s strictly a layperson’s view of the studies being conducted. Nothing here is meant to diagnose a disease or offer therapy for a disorder. If you’re sick, see your doctor. Speak to a physician before using CBD for anything to make sure it’s right for you, especially if you take other medications. These trials are being run by professionals that you can work with if they’re still recruiting subjects. Nothing in the subject of these studies has been proven [that’s why it’s being studied], so it shouldn’t be assumed that CBD works for any of the disorders mentioned.

In this article, we’ll look at some of the clinical trials that are planned or ongoing. We’ll find out what they’re studying and what part of our health they’re interested in. These studies are listed in no particular order. They’re all over the US. This list comes from www.clinicaltrials.gov. If you’re interested in participating in a study, you can go to that site, locate the study, and contact the investigators. If you have an illness or disorder and you want to know if someone is studying CBD for it, you can use the search function to figure that out.

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This study, the first of our current CBD studies examined the link between CBD and CPIN. 

“The purpose of this study is to assess the effect of a hemp-based cannabidiol (CBD) product, Ananda Hemp Spectrum Gelcaps, on the severity and duration of chemotherapy-induced neuropathy (CIPN) among non-metastatic breast, colorectal, uterine and ovarian cancer patients who received neoadjuvant or adjuvant therapy that included neurotoxic chemotherapeutic agents.”

The study information points out that chemotherapy chemicals can cause a lot of negativity in a patient’s life. Neuropathy is one of the most common symptoms. There have already been several studies that show that CBD might help to improve this side effect. The current study will work with 100 patients in a double-blind study to determine if CDB improves the neuropathy these patients are suffering.

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This study, the second of our current CBD studies examined the link between Topical CBD and Joint Arthritis. 

“Rationale: CBD is commonly being used as an over-the-counter treatment for arthritis-related pain, however no clinical trial has been performed to establish efficacy. Hypothesis: CBD is more effective than placebo for relieving pain and improving patient-reported outcomes for thumb basal joint arthritis.”

Millions of people already use CBD to help reduce the pain of arthritis. This double-blind study will use CBD topically for thumb basal joint arthritis. Forty patients will use one product (CBD or placebo) for 2 weeks, then switch over to the other for 2 weeks. It should be interesting to see what results they get from this since everyone, at some point, will use CBD to relieve their arthritis.

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This study, the third of our current CBD studies examined the link between effectiveness of Hemp-Based CBD Oil.

“The investigators are looking to conduct a study looking at the effects of cannabidiol (CBD) from Hemp Oil in patients with Chronic pain, anxiety and insomnia. It is believed that CBD will improve pain anxiety and sleep quality and reduce opioid use. The study will last a total of 4 weeks and involve onsite visits in addition to weekly pain assessments.”

This study might be called “studying what everyone swears CBD does.” These are the core of positive effects that most advocates of CBD swear it helps: sleep, anxiety, and pain. Here, all the subjects will have been using narcotics and/or physical therapy to reduce chronic pain. So this is a study in what might be seen as extreme cases of pain that cause anxiety and insomnia.

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This study, the fourth of our current CBD studies examined the link between CBD and Immune Function.

“Chronic inflammation, which is defined as a persistent, low-grade inflammatory response within the body, is associated with many of the negative health conditions which are prevalent in our society today. It is most well-known for its role in the progression of diseases including obesity, metabolic syndrome, cancer, cardiovascular disease, and diabetes. Chronic inflammation is also linked to many of the underlying factors associated with disease development including perturbations in sleep, and mental health status such as depression, anxiety, fatigue, and quality of life. Natural killer cells, commonly referred to as NK cells, are a subset of white blood cells that play an important role in the coordination of inflammation in the body.”

If they can prove that CBD reduces chronic inflammation in the body, it could change the direction of human health. Everything from fibromyalgia to heart disease can be attributed to inflammation. If this study, and others that have been done and are being done, can show that CBD reduces that, it will make millions of people healthier.

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This study, the fifth of our current CBD studies examined the link between CBD oil and PTSD.

“The overarching objective of the proposed project is to test the clinical efficacy of CBD in the treatment of post-traumatic stress disorder using a rigorous double-blind randomized clinical trial methodology. Participants (n=150) meeting full DSM-5 criteria for post-traumatic stress disorder (PTSD) will be randomized to one of 3 treatment arms: (a) CBD -Isolate; (b) CBD-Broad Spectrum; (c) Placebo oil.”

For those of us in the CBD community, this study will be interesting, as they’re studying CBD isolate and full-spectrum CBD. Look at our other blogs to understand the differences, but CBD isolate is just CBD, while full-spectrum CBD is CBD with all the other cannabinoids, terpenes, and everything else that naturally grows in the plant. It will be exciting to know if there’s a difference shown between the two extracts versus a placebo for something as important as PTSD.

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This study, the sixth of our current CBD studies examined the link between CBD and the emotional impact of COVID.

“The overarching objective of the proposed project is to test the relative clinical efficacy of CBD isolate, full-spectrum CBD oil, and placebo in reducing COVID-Induced stress, anxiety, depression, anger, and sleep disturbance.”

COVID-19 is stressful. Whether you’ve had it and the “long-haul” effects are making life difficult or you’re simply afraid of getting it with all the news and conflicting information, there’s a lot of anxiety and stress related to this disease. It will be interesting to see if CBD, which is readily available, can help people to calm down a bit and feel better. This test will also study CBD isolate and full-spectrum separately versus a placebo.

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This study, the seventh of our current CBD studies examined the link between CBD and agitation in Alzheimer’s patients.

“This is a randomized, double-blinded, placebo-controlled, crossover trial that aims to 1) determine the efficacy of THC-free cannabidiol (CBD oil) in reducing the severity of agitation among participants and 2) determine whether THC-free CBD oil can reduce the burden on caregivers and increase the participants’ quality of life.”

For anyone who has ever lived with or been near someone with Alzheimer’s, you know they can get very upset and angry, “agitated” in the words of this study. Hopefully, they’ll find that CBD can help to reduce that, making things easier on caregivers and allowing patients to live without having to be drugged with narcotics. That CBD is not psychoactive, but might have a positive effect, will be great for those trying to help people with Alzheimer’s.

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This study, the eighth of our current CBD studies examined the link between CBD and Opiod related cravings.

“The purpose of this week-long study is to determine the impact of cannabidiol on cue-induced cravings among individuals with opioid use disorder who are stable on sublingual buprenorphine treatment.”

This is one of many studies looking at how CBD can improve drug and alcohol addiction. In the CBD community, there has been a lot of anecdotal evidence that CBD can reduce craving for opioids, alcohol, and other addictive drugs. This and many of the studies listed on clinicaltrials.gov are looking to study whether CBD can reduce or eliminate those cravings and allow addicts to get control of their disorder. This would provide the world with a great alternative to replacing these drugs with simply less potent forms of them.

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This study, the ninth of our current CBD studies examined the link between CBD and ASD.

“This is a 6-week open trial to identify the optimal dosing of cannabidiol (CBD) in youth with autism spectrum disorder (ASD) and to identify primary and secondary outcomes for future controlled studies. This study will evaluate change in symptoms commonly associated with ASD, as evidence suggests that CBD may be effective in addressing difficulties such as irritability and anxiety, while maintaining a benign adverse effect (AE) profile in children and adolescents.”

One in 54 children in the US are diagnosed with autism, with boys being four times more likely to be diagnosed as being on the autism spectrum than girls. (https://www.autismspeaks.org/autism-statistics-asd)

If CBD can provide some relief from the emotional sides of this disorder, it could help parents and teachers to guide these children better with fewer outbursts and disruptions. This is another place where CBD might replace drugs that cause children to be numb in order to keep their emotions under control. This test will look at 40 children, 7 to 17, and will use Epidolex, a prescription form of CBD, to see if it helps them with their anxiety and irritability.

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This study, the tenth of our current CBD studies examined the link between CBD and driving abilities in healthy adults.

“A randomized, parallel-group, double-blind, exploratory two-arm trial to assess the effects of CBD on driving ability along with changes in psychological status (i.e. mood, drowsiness, sedation) and cognitive function. Forty healthy West Virginia University (WVU) students will be allocated and randomized to receive: (1) 300 mg of pure CBD oil or (N=20) (2) placebo matched in appearance and taste (N=20). After consuming the study drug, each individual will participate in a 25-35-minute driving simulation and their driving performance measured. “

Not every study discovers if CBD has beneficial effects; some studies look for side effects, like impaired driving. Some people report getting drowsy on CBD, while others have said they can’t think clearly. These effects usually disappear after a few days, but this study should tell us if there’s a real problem with CBD, especially the first time you take it, in your ability to drive.

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This study, the eleventh of our current CBD studies examined the link between CBD and Endometriosis Pain.

“The investigators are looking to conduct a study looking at the effects of cannabidiol (CBD) in patients with endometriosis. It is believed that CBD will improve both pain and quality of life. The study will last a total of 12 weeks and involve several onsite visits in addition to daily pain assessments.”

“Endometriosis (en-doe-me-tree-O-sis) is an often painful disorder in which tissue similar to the tissue that normally lines the inside of your uterus — the endometrium — grows outside your uterus.” – Mayo Clinic A non-narcotic, reliable way to reduce endometrial pain would liberate many women who suffer in silence every day.

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This study, the twelfth of our current CBD studies examined the link between CBD and foot problems in diabetics.

“The purpose of the study is to evaluate whether PG-DN-20WS is a better pain reliever in patients with diabetic neuropathic pain of the feet than a placebo.”

Diabetic neuropathy is very common. Most of us know someone who has developed neuropathy since being diagnosed with diabetes. If CBD can reduce that pain without significant side effects, it could be life changing for people who can’t walk comfortably because of this pain. This is a study worth watching since so many older adults are experiencing late-onset Type-II diabetes.

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This study, the thirteenth of our current CBD studies examined CBD as steroid sparing therapy.

“At the conclusion of the dose escalation segment of the study, if the 300 mg Cannabidiol dose level/placebo is deemed safe for two weeks with Standard of care dose of steroids, patients will continue receiving this 300 mg dose/placebo for an additional period of 3 months. Weekly tapering off of steroids will then commence and will be carried out. Three months after starting treatment with Cannabidiol an interim analysis to evaluate Cannabidiol’s safety and efficacy will be carried out and treatment assignment group may be changed (according to response confirmation).”

Crohn’s is a chronic inflammatory disease that affects the lining of the gastrointestinal tract. (Mayo Clinic) It is very painful, and it affects every minute of a person’s life. It’s hoped that CBD can reduce the inflammation and help relieve some symptoms. There is no cure and steroids can only slow the progression of the disease. A new, effective treatment would be a great thing for people who struggle with this disease.

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This study, the fourteenth of our current CBD studies examined CBD as a solution for “long COVID.”

“Long COVID is a common outcome after infection with the SARS-COV-2 virus and the need for treatment and ongoing support for people experiencing long COVID has been increasingly recognised, including through the establishment of dedicated treatment units within the NHS. While symptoms – and their severity – may vary greatly between individuals, some of the common symptoms associated with long COVID include fatigue, breathlessness, pain and sleep disturbances. In this study we will test the feasibility of a broad spectrum cannabidiol dominant formulation (Medicabilis) for treating these symptoms in people with a diagnosis of long COVID.”

In the press, this is often called “long-haul” COVID. Many people who get COVID struggle with symptoms for months or years afterward. Since the disease is so new, we do not know how to treat it, how long it will last, or if it will get worse. Since CBD has been shown to reduce inflammation, it might help reduce the symptoms of long COVID without narcotics or drugs with massive side effects.

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We hope you enjoyed this article on current CBD studies. Keep in mind that there is a difference between hemp-based CBD products (which are free of THC) and CBD products derived from other types of cannabis plants.

When you go to ClinicalTrials.gov and look only for those CBD studies that are active or completed, you find 648 of them (as of 8/11/21). That means that there are literally hundreds of possibilities that CBD will be discovered to have a positive effect on some or many diseases, disorders, symptoms, or addictions.

For those in the CBD community, we hope that the anecdotes that are constantly being written about and spoken of are true. While we don’t expect CBD to be a cure-all, we do hope that significant effects, like reduction of inflammation, will be proven. That could change the lives of hundreds of millions of people.

Again, we need to note this is not written by doctors. This article is just a layperson’s look at publicly available information. It’s not meant to diagnose or treat any disorder. See your physician before you use CBD for anything and report any side effects to her/him if you experience anything. Be safe and smart, particularly if you’re taking other medications.

As all types of CBD based products become more popular, we hope to see more rigorous scientific research on how useful, safe, and effective they can be for consumers. Are you eager to start your own Private Label CBD product line? Why not choose a reputable, transparent CBD manufacturing partner? Fill out the form below to get your free CBD product quote today.